Hair Growth Kit Clinical Study
HAIR GROWTH CYCLE
The importance of hair in our lives cannot be overstated. Whether men or women lose their hair, they lose much more than their natural, youthful appearance. People also lose their self-esteem and self-confidence associated with healthy looking hair. Hair loss also, called alopecia, is a common problem affecting both men and women.
Normal hair follicle is surrounded by healthy connective tissue and dermal papilla, and has minimal or absence of inflammation nor oxidative stress. Hair loss sufferers will most of the time have the hair growth cycle disrupted by an increase of dihydrotestosterone (DHT) hormone, loss of connective tissue integrity surrounding the hair follicle, and an increase of the inflammatory process and oxidative stress in the scalp. With age, the decrease number and size of hair follicles in the scalp will also lead to thinner hair and an increase in hair loss.
SYNERGISTIC ACTION OF A PEPTIDE AND RED CLOVER EXTRACT
HRS-10 is a biomimetic peptide (acetyl tetrapeptide-3) combined with a red clover extract rich in Biochanin A. HRS-10 efficacy is based on the association and synergistic action of its two ingredients.
HRS-10 has a direct action on 5- a-reductase which modulates dihydrotestosterone (DHT) to help prevent hair miniaturization. It improves ECM proteins integrity in dermal papilla for a better hair anchoring and reduces damages caused by inflammation, providing fuller, thicker and healthier looking hair.
TARGETTING THE CAUSES OF HAIR LOSS
ECM renewal and anchoring improvement
Hair follicles size is determined by:
- T he volume of its dermal papilla;
- T he volume of the extracellular matrix.
Healthy dermal papilla will produce good ECM proteins such as collagen type III and anchoring fibers such as laminin and collagen VII which will favor a good hair anchoring in the bulb surrounding tissue. If improper ECM renewal, hair will eventually lack vigor and will thin. Cycle after cycle, the follicle becomes smaller and finally, miniaturized and fall.
Quantification of laminin, type III collagen synthesis induced by Acetyl tetrapeptide-3 on fibroblasts. It has been demonstrated that molecules which have an activity on these ECM proteins stimulation, also increase hair follicle size and improve hair anchoring.
Acetyl tetrapeptide-3 stimulates dermal papilla extracellular matrix proteins, and thus has a direct effect on structures surrounding hair follicles.
Collagen VII is a major constituent of the anchoring fibrils and is located in the basement membrane (DEJ) around the papilla. In this experiment, corticoids are used to induce a decrease in the hair papilla cells growth and ECM protein.
Acetyl tetrapeptide-3 provides a repairing effect at the dermal-epidermal junction level, helping hair anchoring.
IMPROVING HAIR FOLLICLE LENGTH
Human hair follicles in anagen phase are isolated from skin biopsys and cultured with or without Acetyl tetrapeptide-3 for 8 days.
Acetyl tetrapeptide-3 improves by 35% the length in comparison with untreated areas after 8 days of treatment.
PROVIDING FULLER AND THICKER LOOKING HAIR
- 30 men with androgenetic alopecia: 15 treated with the HRS-10 lotion (5%) and 15 with a placebo.
- Daily application of 20 drops of the HRS-10 lotion or placebo for a period of 4 months.
- A digital trichogram (TrichoScan professional) was taken at D0 and 4 months later.
These products induce a visible increase in the anagen hair density in comparison with placebo.
A/T ratio = Comparison of the number of anagen and telogen hair, which is an indication of the percentage of active hair follicles.